Bulk 2,6-Difluorobenzamide (DFBA)
CAS No: 18063-03-1
Chemical Name: 2,6-Difluorobenzamide
Synonyms2,6-difluorobenzoic acid amide;uorobenzamide;2,6-Difluorbenzamid;2,6-DIFLUOROBENZAMIDE;2,6-difluoro-benzamid;2，6-difluorobenzaminde;2,6-Difluorobenzoamide;2,6-Difluorobenzoylamide;2,6-Difluorobenzamide97%;2,6-Difluorobenzamide>
CBNumber: CB5376515
Molecular Formula: C7H5F2NO
Molecular Weight: 157.12
MDL Number: MFCD00007972
MOL File: 18063-03-1.mol
2,6-Difluorobenzamide Properties
| Melting point | 145-148 °C (lit.) |
|---|---|
| Boiling point | 51-52C/15Tor |
| Density | 1,199g/cm |
| refractive index | 1,508 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ethanol: soluble5%, clear to turbid, colorless to light yellow |
| form | Solid |
| pka | 14.54±0.50(Predicted) |
| color | Off-White |
| BRN | 2047480 |
| InChIKey | AVRQBXVUUXHRMY-UHFFFAOYSA-N |
| LogP | 0.011-0.25 at 25℃ |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
2,6-Difluorobenzamide Chemical Properties,Uses,Production
Chemical Properties
white to yellowish powder
Uses
2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates. It is also used in the synthesis of pesticide intermediates, which can be used to produce various insecticides such as fluazuron, chlorpyrifos, and pyrethroids.
Preparation
2,6-Difluorobenzamide is obtained by hydrolysis of 2,6-difluorobenzonitrile.
Synthesis
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General procedure for the synthesis of 2,6-difluorobenzamide from 2,6-difluorobenzonitrile: (1) 100 g (0.72 mol) of 2,6-difluorobenzonitrile was added slowly and dropwise to a mixed solution of 240 g of concentrated sulfuric acid and 24 ml of water at room temperature. The reaction mixture was stirred at 80°C to 85°C for 12 hours. After completion of the reaction, the mixture was slowly poured into 1.2 kg of ice water and stirred continuously for 30 minutes, followed by filtration. The resulting crystals were washed to neutrality with distilled water and finally dried under vacuum at 85°C. The yield was 91.0 g (80.6% yield) with a melting point of 140°C to 141.5°C.
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